NIMH-funded researchers are connecting the dots between inflammation in a pregnant human mother and possible effects on her young child’s developing brain. So far, they have linked high levels of maternal inflammation during pregnancy to reduced brain circuit communications and altered long-distance brain wiring at birth, poorer cognitive function at one year – and to reduced impulse control and working memory at two years.
Inflammation and mental illness
Inflammation is part of the body’s normal defense against environmental insults, such as infections. In addition, the body can mount inflammatory responses to a host of factors, including obesity, diet, drugs (e.g., smoking), maternal depression, poverty, and stress.