Researchers at University of California San Diego School of Medicine have determined that psychological resilience has a positive effect on health outcomes for people living with schizophrenia. This is the first study to quantitatively assess the effects of both childhood trauma and psychological resilience on health and metabolic function in people living with schizophrenia.
Globally 1 percent of people suffer from schizophrenia, a chronic and severe mental disorder that can affect all types of people and greatly impacts how a person thinks, feels and behaves. The psychiatric symptoms are typically treated with antipsychotic drugs; however, persons with schizophrenia are also more vulnerable to physical disorders, such as diabetes and cardiovascular disease and premature death. Although the cause of schizophrenia is not entirely known, the disorder is linked to genetic and environmental risk factors, including childhood adversity.
Antipsychotic drugs — which transformed mental health care following their chance discovery in the mid-20th Century — may finally be poised for a long-overdue makeover incorporating structure-based design. Scientists funded by the National Institutes of Health have achieved a landmark of psychiatric neuropharmacology: deciphering the molecular structure of a widely prescribed antipsychotic docked in its key receptor. They are hopeful that this discovery may hold secrets to designing better treatments for schizophrenia, bipolar disorder, and other mental illnesses.
“For the first time, we can understand precisely how atypical antipsychotic drugs bind to their primary molecular target in the human brain,” explained Dr. Laurie Nadler, chief of the neuropharmacology program at the National Institute of Mental Health (NIMH), which co-funded the study along with the National Institute of General Medical Sciences and the National Cancer Institute. “This discovery opens the way for the rational design of a new generation of antipsychotic drugs, hopefully with more desirable effects and fewer side effects.”