The ways of wisdom in schizophrenia

While wisdom is closely linked to improved health and well-being, its role and impact among persons with schizophrenia, possibly the most devastating of mental illnesses, is not known.

In a new paper, publishing February 14, 2019 in Schizophrenia Research, researchers at University of California San Diego School of Medicine report that, on average, persons with schizophrenia (PwS) obtained lower scores on a wisdom assessment than non-psychiatric comparison participants (NPCPs), but that there was considerable variability in levels of wisdom. Nearly one-third of PwS had scores in the “normal” range, and these PwS with higher levels of wisdom displayed fewer psychotic symptoms as well as better cognitive performance and everyday functioning.

“Taken together, our findings argue for the value of assessing wisdom in persons with schizophrenia because increasing wisdom may help improve their social and neuro-cognition, and vice versa,” said senior author Dilip Jeste, MD, Distinguished Professor of Psychiatry and Neurosciences and director of the Stein Institute for Research on Aging at UC San Diego School of Medicine.

Full story at Science Daily

Have researchers found a new risk factor for schizophrenia?

Scientists have located an intriguing link between schizophrenia and the Epstein-Barr virus, a type of herpes virus. Now, they need to determine which way the risk lies.

Schizophrenia, a condition characterized by a confused perception of reality, delusions, and altered behavior, affects more than 21 million people globally.

In a new study, specialists from Johns Hopkins Medicine in Baltimore, MD, and the Sheppard Pratt Health System in Townson, MD, found evidence that links schizophrenia with the Epstein-Barr virus.

This is a herpes virus that causes infectious mononucleosis, or glandular fever.

Full story at Medical News Today

Brains of people with schizophrenia-related disorders aren’t all the same

A new multi-site brain imaging study in The American Journal of Psychiatry shows that sub-groups of people use their brains differently when imitating emotional faces — a task that reflects their ability to interact socially. Interestingly, individuals with schizophrenia do not have categorically different social brain function than those without mental illness, but fall into different sub-groups that may respond to different types of treatments. These findings call into question the most common research approaches in mental health.

“We know that, on average, people with schizophrenia have more social impairment than people in the general population,” says senior author Dr. Aristotle Voineskos in the Campbell Family Mental Health Research Institute at the Centre for Addiction and Mental Health (CAMH) in Toronto. “But we needed to take an agnostic approach and let the data tell us what the brain-behavioural profiles of our study participants looked like. It turned out that the relationship between brain function and social behaviour had nothing to do with conventional diagnostic categories in the DSM-5 (Diagnostic and Statistical Manual of Mental Disorders).”

Full story at Science Daily

Targeted cognitive training benefits patients with severe schizophrenia

Schizophrenia is among the most difficult mental illnesses to treat, in part because it is characterized by a wide range of dysfunction, from hallucinations and mood disorders to cognitive impairment, especially verbal and working memory, which can be explained in part by abnormalities in early auditory information processing.

In recent years, targeted cognitive training (TCT) has emerged as a promising therapeutic intervention. TCT uses computerized training, such as sophisticated brain games, to target specific neural pathways, such as memory, learning and auditory-based senses, to beneficially alter the way they process information.

But while TCT has proven effective for mild to moderate forms of schizophrenia under carefully controlled conditions, it remains unclear whether the approach might benefit patients with chronic, refractory schizophrenia treated in non-academic settings, such as those cared for in locked residential rehabilitation centers.

Full story at Science Daily

Hyperconnectivity in a brain circuit may predict psychosis

National Institute of Mental Health (NIMH)-funded scientists have discovered a pattern in the way a brain circuit works that may help predict the onset of psychosis. High levels of chatter, or “hyperconnectivity,” in a circuit involving the cerebellum, thalamus, and cortex emerged as a potential “neural signature” in a functional magnetic resonance imaging (fMRI) study by Tyrone Cannon, Ph.D.of Yale University and colleagues.

The degree of hyperconnectivity within this circuit predicted the length of time it took for an individual to convert from a state of risk to full psychosis – hallucinations, delusions, and disorganized thought and behavior. The researchers also found this same pattern of hyperactivity in a separate group of individuals with schizophrenia.

Full story at NIMH

Please Stop Merchandising Mental Illness

I was seeing a guy from London, and he told me Scott and Zelda Fitzgerald were his favorite couple. He was charming, exciting and “got” me. His choice sounded so romantic, so like him.

Obviously I knew who they were, but I wasn’t familiar with the details of their relationship. I lay in bed and Googled eagerly. Was this the kind of great love he envisioned for us?

Zelda Fitzgerald was intensely glamorous and hauntingly beautiful. Scott called her the original flapper. Oh, and they had a turbulent relationship wracked with infidelity and excessive drinking: a love affair that ended with her dying after a fire broke out in the mental institution where she was a patient. She was schizophrenic and spent the last of her years hospitalized.

Full story at The New York Times

Stress affects people with schizophrenia differently

Stressful situations affect the brain and body differently in people with schizophrenia compared to people without the mental illness or individuals at high risk for developing psychosis, a new CAMH study shows. The relationship between two chemicals released when people experienced stress — one released in the brain and the other in saliva — differs in people with schizophrenia. The discovery, recently published in the journal Brain, may provide clues into how to act early to prevent schizophrenia.

“We found a disrupted stress response in people with schizophrenia, which did not occur in either healthy individuals or people at clinical high risk for developing psychosis,” says Dr. Christin Schifani, Postdoctoral Research Fellow in the Research Imaging Centre in CAMH’s Campbell Family Mental Health Research Institute, and lead author of the study.

As most people with schizophrenia experience psychosis, identifying differences between people at high risk for psychosis and those with schizophrenia may shed light on how schizophrenia develops and ways to prevent its onset.

Full story at Science Daily

People with schizophrenia account for more than one in 10 suicide cases

A new CAMH and Institute for Clinical Evaluative Sciences (ICES) study shows that people with schizophrenia account for more than 1 in 10 cases of suicide in Ontario, and that young people are disproportionately affected.

“Among people who died by suicide, having a diagnosis of schizophrenia is clearly over-represented,” says Dr. Juveria Zaheer, first author and Clinician Scientist in CAMH’s Institute for Mental Health Policy Research.

The study, published in Schizophrenia Research, showed that 12 per cent of all suicide cases involved a diagnosis of schizophrenia. Approximately one per cent of the population has the disorder.

Full story at Science Daily

Brain abnormality indicates general risk for mental illness

A new study by researchers at Duke University reports an abnormality in visual regions of the brain that is associated with a person’s general risk for mental illness. The findings, published in Biological Psychiatry, indicate a signature abnormality shared between common forms of mental illness, which could help clinicians assess a patient’s general risk for developing a mental illness. The signature abnormality was present in participants involved in the study who already had a higher risk of mental illness. This was characterized by a reduced efficiency between visual areas and brain networks important for integrating sensory information and suppressing distracting information.

Researchers have long thought that some aspects of the biology of the risk for psychiatric disorders were specific to particular disorders, and by studying specific groups of patients, may have mistaken general risk factors as specific risk factors. Newer research suggests that a person’s risk for developing mental illness is not specific to one form of disorder, but is instead shared across many different disorders. “In other words, there may be a single risk factor that predicts whether an individual develops any form of psychiatric disorder, be it depression, post-traumatic stress disorder, addiction, or even schizophrenia,” said first author Maxwell Elliott, a doctoral student in the laboratory of Ahmad Hariri, PhD.

Full story at Science Daily

Resilience counteracts effects of childhood abuse and neglect on health

Researchers at University of California San Diego School of Medicine have determined that psychological resilience has a positive effect on health outcomes for people living with schizophrenia. This is the first study to quantitatively assess the effects of both childhood trauma and psychological resilience on health and metabolic function in people living with schizophrenia.

Globally 1 percent of people suffer from schizophrenia, a chronic and severe mental disorder that can affect all types of people and greatly impacts how a person thinks, feels and behaves. The psychiatric symptoms are typically treated with antipsychotic drugs; however, persons with schizophrenia are also more vulnerable to physical disorders, such as diabetes and cardiovascular disease and premature death. Although the cause of schizophrenia is not entirely known, the disorder is linked to genetic and environmental risk factors, including childhood adversity.

Full story at Science Daily