antidepressant

New theory may explain cause of depression and improve treatments

A new area in depression research suggests dysfunction in mitochondria — the main source of energy for cells — could lead to major depression. Published in Frontiers in Neuroscience, this new insight to long-held theories on the causes of depression could lead to the development of novel and more effective antidepressant drugs. Depression is a highly prevalent disorder affecting up to 20% of the population. It is commonly thought to be caused by a chemical imbalance…

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Don’t let depression keep you from exercising

Exercise may be just as crucial to a depression patient’s good health as finding an effective antidepressant. A new study of nearly 18,000 participants found that those with high fitness at middle age were significantly less likely to die from heart disease in later life, even if they were diagnosed with depression. The research — a collaboration between UT Southwestern and The Cooper Institute — underscores the multiple ways in which depression may ultimately impact…

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Having an abortion does not lead to depression

Having an abortion does not increase a woman’s risk for depression, according to a new study of nearly 400,000 women published today in JAMA Psychiatry. While previous research has found abortion does not harm women’s mental health, studies claiming that it does continue to be published and state policies that restrict access to abortion in the United States have been justified by claims that abortion causes women psychological harm. To better understand the relationship between having…

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Antidepressant response within hours? Experts weigh evidence on ketamine as fast-acting treatment for depression

Recent studies suggest that ketamine, a widely used anesthetic agent, could offer a wholly new approach to treating severe depression — producing an antidepressant response in hours rather than weeks. Two reviews of recent evidence on ketamine and related drugs for treating depression appear in the Harvard Review of Psychiatry, published by Wolters Kluwer. Ketamine and related drugs may represent a “paradigm shift” in the treatment of major depressive disorder (MDD) and bipolar depression — especially…

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Arthritis drug boosts effectiveness of antidepressant medication

Giving severely depressed patients the arthritis drug celecoxib (Celebrex®) dramatically boosted the effectiveness of their antidepressant medication, a Loyola study has found. Loyola Medicine psychiatrist Angelos Halaris, MD, PhD, presented the study at the Fifth International Congress on Psychiatry and the Neurosciences in Athens, Greece. Dr. Halaris is a professor in the Department of Psychiatry and Behavioral Neurosciences of Loyola University Chicago Stritch School of Medicine. The eight-week study enrolled bipolar adults, aged 18 to…

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Scientists find new path in brain to ease depression

Northwestern Medicine scientists have discovered a new pathway in the brain that can be manipulated to alleviate depression. The pathway offers a promising new target for developing a drug that could be effective in individuals for whom other antidepressants have failed. New antidepressant options are important because a significant number of patients don’t adequately improve with currently available antidepressant drugs. The lifetime prevalence of major depressive disorder is between 10 to 20 percent of the…

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Depression experts question effectiveness of stress hormone drug

Pioneering research by mood disorder experts at Newcastle University has questioned the effectiveness of metyrapone, a drug suggested to treat depression. It is well recognised that stress can lead to an episode of depressive illness and some patients have raised levels of the stress hormone, cortisol, in their body as an indication of the mental health condition. Now the largest study of its kind has shown that a drug that blocks production of stress hormone…

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Antidepressant drug linked with increased risk of birth defects when taken in early pregnancy

Using paroxetine — a medication prescribed to treat conditions including depression, obsessive-compulsive disorder, anxiety and posttraumatic stress disorder — during the first trimester of pregnancy may increase newborns’ risk of congenital malformations and cardiac malformations. That’s the conclusion of a recent analysis published in the British Journal of Clinical Pharmacology. Up to one-fifth of women of childbearing age experience depressive symptoms that often lead to mild to moderate depression, and prescriptions for antidepressants during pregnancy have…

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Two-drug combo helps older adults with hard-to-treat depression

More than half of older adults with clinical depression don’t get better when treated with an antidepressant. But results from a multicenter clinical trial that included Washington University School of Medicine in St. Louis indicates that adding a second drug — an antipsychotic medication — to the treatment regimen helps many of those patients. The findings, from a study of 468 people over age 60 and diagnosed with depression, are published in The Lancet. The study…

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New compounds may treat depression rapidly with few side effects

A new study by researchers at University of Maryland School of Medicine has identified promising compounds that could successfully treat depression in less than 24 hours while minimizing side effects. Although they have not yet been tested in people, the compounds could offer significant advantages over current antidepressant medications. The research, led by Scott Thompson, PhD, Professor and Chair of the Department of Physiology at the University of Maryland School of Medicine (UM SOM), was…

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