Largest Ever Genome-Wide Association Study Finds Genetic Risk Factors for Anxiety

The largest study ever conducted on genetic risk factors for anxiety, a genome-wide association study (GWAS) of 200,000 participants recently published in the American Journal of Psychiatry, found significant associations between self-reported anxiety and specific single nucleotide polymorphisms (SNPs). Daniel Levey, PhD, from the department of psychiatry, Yale University School of Medicine, New Haven, Connecticut, and colleagues pulled data from one of the largest biobanks in the world, the Million Veteran Program. To assess anxiety and related…

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Researchers identify 20 novel gene associations with bipolar disorder

In the largest study of its kind, involving more than 50,000 subjects in 14 countries, researchers at the Icahn School of Medicine at Mount Sinai and more than 200 collaborating institutions have identified 20 new genetic associations with one of the most prevalent and elusive mental illnesses of our time — bipolar disorder. The study is reported in the May 2019 issue of Nature Genetics. The elevated morbidity and mortality associated with bipolar disorder make it…

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Personality traits, psychiatric disorders linked to specific genomic locations

A meta-analysis of genome-wide association studies (GWAS) has identified six loci or regions of the human genome that are significantly linked to personality traits, report researchers at University of California San Diego School of Medicine in this week’s advance online publication of Nature Genetics. The findings also show correlations with psychiatric disorders. “Although personality traits are heritable, it has been difficult to characterize genetic variants associated with personality until recent, large-scale GWAS,” said senior author Chi-Hua…

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