Neurons’ response to seizure-induced stress reduces seizure severity

In response to seizures, the endoplasmic reticulum (ER), a network of flattened tubes in the cell that packages and transports proteins, triggers a stress response that reduces brain activity and seizure severity. The new findings, reported by Nien-Pei Tsai and colleagues at University of Illinois at Urbana-Champaign on 26th September in PLOS Genetics, may have important implications for the development of new epilepsy therapies. For one-third of epilepsy patients, existing anti-epileptic drugs don’t effectively prevent the…

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How Might New Neurons Buffer Against Stress?

Over the past decade or so, evidence has emerged suggesting that the birth of new neurons in the adult brain’s memory hub, or hippocampus, may play a key role the action of antidepressants, resilience to stress, the benefits of exercise and enriched environments and preventing memory loss. But understanding how it might work has remained elusive. Heather Cameron,Ph.D., chief of the NIMH intramural Unit on Neuroplasticity, discussed findings of ongoing studies on the function of adult neurogenesis in the hippocampus at a…

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